Jean E Schaffer Selected Research

Biomarkers (Surrogate Marker)

12/2020	Application of a glycinated bile acid biomarker for diagnosis and assessment of response to treatment in Niemann-pick disease type C1.
1/2020	Circulating ceramide ratios and risk of vascular brain aging and dementia.
1/2020	Alterations in plasma triglycerides and ceramides: links with cardiac function in humans with type 2 diabetes.
11/2014	Cholesterol homeostatic responses provide biomarkers for monitoring treatment for the neurodegenerative disease Niemann-Pick C1 (NPC1).
10/2013	Identification of Niemann-Pick C1 disease biomarkers through sphingolipid profiling.

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Jean E Schaffer Research Topics

Disease

10	Obesity 01/2018 - 04/2003
8	Cardiomyopathies (Cardiomyopathy) 02/2016 - 04/2002
6	Type C Niemann-Pick Disease (Niemann Pick Disease, Type C) 12/2020 - 03/2008
6	Insulin Resistance 01/2020 - 03/2003
6	Heart Failure 01/2020 - 04/2002
5	Inflammation (Inflammations) 01/2021 - 12/2012
5	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2020 - 09/2006
5	Type 2 Diabetes Mellitus (MODY) 01/2020 - 12/2005
4	Disease Progression 10/2019 - 09/2006
4	Diabetic Cardiomyopathies 02/2016 - 04/2002
4	Metabolic Diseases (Metabolic Disease) 01/2016 - 07/2009
3	Fibrosis (Cirrhosis) 01/2017 - 09/2004
2	Dementia (Dementias) 01/2020 - 05/2015
2	Coronary Disease (Coronary Heart Disease) 01/2020 - 01/2018
2	Mitochondrial Diseases (Mitochondrial Disease) 01/2018 - 02/2015
2	Weight Loss (Weight Reduction) 01/2018 - 05/2015
2	Heart Diseases (Heart Disease) 02/2015 - 04/2002
2	Diabetes Complications 10/2012 - 07/2011
2	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 05/2006 - 09/2004
1	Alzheimer Disease (Alzheimer's Disease) 01/2020
1	Diabetes Mellitus 01/2018
1	Autosomal Dominant Optic Atrophy (Dominant Optic Atrophy) 01/2018
1	Liver Cirrhosis (Hepatic Cirrhosis) 01/2017
1	Non-alcoholic Fatty Liver Disease 01/2017
1	Hypoxia (Hypoxemia) 06/2015
1	Ataxia (Dyssynergia) 05/2015
1	Emphysema 02/2015
1	Cardiomegaly (Heart Hypertrophy) 02/2015
1	Chronic Obstructive Pulmonary Disease (COPD) 02/2015
1	Dyslipidemias (Dyslipidemia) 02/2013
1	Necrosis 02/2013
1	Glucose Intolerance 08/2010
1	Hypertrophy 12/2009
1	Atherosclerosis 06/2008
1	Hyperlipidemias (Hyperlipidemia) 02/2005
1	Niemann-Pick Diseases (Niemann Pick Disease) 07/2003
1	Intellectual Disability (Idiocy) 04/2002
1	X-Linked Mental Retardation (Mental Retardation, X Linked) 04/2002

Drug/Important Bio-Agent (IBA)

24	LipidsIBA 01/2021 - 04/2002
13	CholesterolIBA 12/2020 - 07/2003
10	Fatty Acids (Saturated Fatty Acids)IBA 02/2016 - 04/2002
8	SphingolipidsIBA 12/2020 - 02/2013
8	CeramidesIBA 01/2020 - 02/2013
6	Triglycerides (Triacylglycerol)IBA 01/2020 - 12/2005
5	Biomarkers (Surrogate Marker)IBA 12/2020 - 10/2013
3	Insulin (Novolin)FDA Link 01/2017 - 02/2013
3	Fatty Acid Transport Proteins (Fatty Acid Transport Protein)IBA 02/2015 - 04/2003
3	Ligases (Synthetase)IBA 12/2012 - 04/2002
3	Acyl Coenzyme A (Acyl CoA)IBA 12/2009 - 09/2004
2	Bile Acids and Salts (Bile Acids)IBA 12/2020 - 01/2016
2	Proteins (Proteins, Gene)FDA Link 01/2020 - 01/2018
2	Small Nucleolar RNA (snoRNA)IBA 01/2018 - 06/2015
1	Fenofibrate (CiL)FDA LinkGeneric 01/2020
1	CyclodextrinsIBA 10/2019
1	Mitochondrial Proteins (Mitochondrial Protein)IBA 01/2018
1	Dynamins (Dynamin)IBA 01/2018
1	Phosphotransferases (Kinase)IBA 01/2018
1	MSDC-0602IBA 01/2017
1	FructoseIBA 01/2017
1	Monocarboxylic Acid TransportersIBA 01/2017
1	Trans Fatty AcidsIBA 01/2017
1	ThiazolidinedionesIBA 01/2017
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 01/2017
1	InsulinsIBA 02/2016
1	MicroRNAs (MicroRNA)IBA 01/2016
1	Messenger RNA (mRNA)IBA 06/2015
1	GlycosphingolipidsIBA 02/2015
1	SphingomyelinsIBA 02/2015
1	CatalaseIBA 02/2015
1	TrihexosylceramidesIBA 02/2015
1	Oxidants (Oxidizing Agents)IBA 02/2015
1	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 02/2015
1	Reactive Oxygen Species (Oxygen Radicals)IBA 02/2013
1	PalmitatesIBA 02/2013
1	stearic acid (magnesium stearate)FDA LinkGeneric 02/2013
1	Myosin Heavy Chains (Myosin Heavy Chain)IBA 12/2012
1	Indicators and Reagents (Reagents)IBA 09/2009
1	HDL CholesterolIBA 09/2009
1	Glycated Hemoglobin (Glycosylated Hemoglobin)IBA 09/2009
1	Lipoproteins (Lipoprotein)IBA 06/2008
1	SterolsIBA 06/2008
1	Phenobarbital (Luminal)FDA Link 03/2008
1	Cysteine (L-Cysteine)FDA Link 03/2008
1	Thioctic Acid (Lipoic Acid)IBA 05/2006
1	Nonesterified Fatty Acids (NEFA)IBA 12/2005
1	Complementary DNA (cDNA)IBA 09/2004
1	LeptinIBA 09/2004
1	LDL CholesterolIBA 07/2003
1	LDL Lipoproteins (beta Lipoproteins)IBA 07/2003
1	Retroelements (Retrotransposon)IBA 04/2003
1	Coenzyme A (CoA)IBA 04/2002

Therapy/Procedure

1	Bariatric Surgery 01/2018
1	Gastric Bypass (Roux-en-Y Gastric Bypass) 01/2018
1	Therapeutics 01/2011